Methallylescaline

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists the dose range of methallylescaline as 40 to 65 mg and its duration as 12 to 16 hours.^[1][9][10] As such, its dose range is relatively narrow.^[1][9][10] Moreover, the drug has been reported to have an unusually steep dose–response curve, such that a small increase in dose can result in an unexpectedly large increase in effects.^[11][12] Methallylescaline has about 6 times the potency of mescaline, which has a much higher listed dose range of 200 to 400 mg.^[9][10][1] Its onset is within 1 hour and peak effects occur within 2 hours.^[1]

Shulgin has described methallylescaline as a "mixed bag" in terms of experience reports.^[1] Its effects have been reported to include closed-eye visuals or mental imagery, "visual theater", open-eye visuals, visual distortions, visual depth and movement effects, kaleidoscopic neon colors, watercolors, fantasy, feelings of unreality, easy childhood memory recall, self-connectedness, eroticism, initial discomfort, overload, feeling overwhelmed, shades of possible amnesia, loss of contact, extreme restlessness, trouble sleeping, and enhanced dreams.^[1] It was also reported to produce quite strong body effects, diuretic effects, and slightly reduced heart rate.^[1] Some found it unpleasant and said that they would not repeat the experience, whereas others were impressed by it, found it enjoyable, and called it "beautiful".^[1] Many expressed that the dose they tried was too strong for them and that a lower dose would be better.^[1] Methallylescaline has been described as having relatively more visual imagery than other scalines like cyclopropylmescaline and allylescaline.^[1]

Others have noted that methallylescaline has strong visual effects, as well as prominent nausea, vomiting, and body load, including feeling "overstimulated.^[11] The drug is frequently compared to mescaline.^[11]

Methallylescaline, also known as 4-methylallyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine and scaline.^{[1][3][9][10]} It is a synthetic derivative of mescaline (3,4,5-trimethoxyphenethylamine) with a methallyloxy group instead of methoxy group at the 4 position.^{[1][3][9][10]}

Methallylescaline was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).^[3][1][9] It was first tried by Shulgin in 1981 and its hallucinogenic effects were discovered by him in 1982.^[22][10] The drug has an entry in PiHKAL, but not in Shulgin's 2011 book The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds.^[3] It was encountered as a novel designer drug in Europe by 2013.^[6][7][8] Methallylescaline's pharmacology was described by Matthias Liechti and Daniel Trachsel and colleagues in 2021.^[5] Discussion of methallylescaline online began increasing in late 2023.^[11]

• Scaline