Prosultiamine

From Wikipedia, the free encyclopedia

AHFS/Drugs.comInternational Drug Names
Routes of
administrationOral
ATC code
  • None
Legal status
  • In general: ℞ (Prescription only)
Prosultiamine
Skeletal formula of prosultiamine
Ball-and-stick model of the prosultiamine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(1E)-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.000.397 Edit this at Wikidata
Chemical and physical data
FormulaC15H24N4O2S2
Molar mass356.50 g·mol−1
3D model (JSmol)
  • O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C

Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency.[1][2][3] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.[4][5]

See also

References

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