Protein deacetylase
Class of enzymes
From Wikipedia, the free encyclopedia
A protein deacetylase is any enzyme that removes acetyl groups from lysine amino acids in proteins.[1] That is, it performs deacetylation.
The main ones are histone deacetylases (HDACs) and sirtuins (SIRT1,2,3,5).[2]
Because histone proteins were the first known substrate for protein deacetylases, the latter all tend to be called HDACs of one class or another.[citation needed]
Human protein deacetylase enzymes have been categorized into
- Class I (HDAC1,2,3,8);
- Class II (HDAC4,5,6,7,9,10),
- Class III (SIRT1,2,3,5,6),
- Class IV (HDAC11 and its related enzymes).
Class III are the NAD+-dependent protein deacetylases.