Protopine 6-monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Protopine 6-monooxygenase (EC 1.14.14.98) is an enzyme that catalyzes the chemical reaction
| protopine 6-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.98 | ||||||||
| CAS no. | 128561-60-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are protopine, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and oxygen. ts initial benzylisoquinoline alkaloid product is 6-hydroxyprotopine but this spontaneously forms dihydrosanguinarine.[1][2] NADP+ and water are the by-products.[3]
The systematic name of this enzyme class is protopine,NADPH:oxygen oxidoreductase (6-hydroxylating). It is also called protopine 6-hydroxylase.
