Pseudomonas reptilivora
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| Pseudomonas reptilivora | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Pseudomonadati |
| Phylum: | Pseudomonadota |
| Class: | Gammaproteobacteria |
| Order: | Pseudomonadales |
| Family: | Pseudomonadaceae |
| Genus: | Pseudomonas |
| Species: | P. reptilivora |
| Binomial name | |
| Pseudomonas reptilivora Caldwell and Ryerson 1940 | |
Pseudomonas reptilivora is a fluorescent, yellow-green, Gram-negative, rod-shaped, non-spore-forming, multiple polar flagellated, motile bacterium that is pathogenic to reptiles. It was originally isolated in Gila monsters (Heloderma suspectum), horned lizards (Phrynosoma solare), and chuckawallas (Sauromalus ater).[1] The type strain is ATCC 14836.
P. reptilivora has demonstrated a remarkable ability to convert glucose into gluconic acid, a valuable organic acid widely used in the food, pharmaceutical, and eco-friendly cleaning industries. This bioconversion occurs through an oxidative process catalyzed by membrane-bound dehydrogenases, particularly pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase.[2]
Metabolic pathway
Gluconic acid is synthesized via direct oxidation of glucose in the periplasmic space, bypassing central metabolic pathways which is further oxidized to 2-ketogluconic acid by gluconic acid dehydrogenase, however, another enzyme (2-ketogluconate dehydrogenase) transforms 2-ketogluconic acid into 5-ketogluconic acid at an optimal pH 5.5 and 6.0.[3]
The enzymatic reaction follows:
Glucose + O2 → Gluconic acid + H2O2 [2]
Gluconic acid → 2-ketogluconic acid → 5-ketogluconic acid [2][3]