Pyrroloquinoline-quinone synthase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, pyrroloquinoline-quinone synthase (EC 1.3.3.11) is an enzyme that catalyzes the chemical reaction
-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylic_acid.svg)
The substrates of this enzyme are 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylic acid (AHQQ)[1] and three equivalents of oxygen. Its products are the redox cofactor pyrroloquinoline quinone, two equivalents of hydrogen peroxide, and one of water.[2][3] The details of the stereochemistry of the starting material are not known,[4][5] although the structure of the enzyme from Klebsiella pneumoniae has been established.[6]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinol ine-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing). This enzyme is also called PqqC.
