QNG1

Queuosine 5'-phosphate N-glycosylase/hydrolase (also called queuosine salvage protein) is protein which in humans is encoded by the gene QNG1 (previously C9orf64).^[5] The function and biological process of the queuosine salvage protein is a queuosine-nucleotide N-glycosylase/hydrolase (QNG1) that releases queuine from Q-5'-monophosphate, and this activity is required for the salvage of queuine from exogenous Queuosine by S. pombe and HeLa cells.^[6] Some evidence from orthologs indicates it may be involved in tRNA processing and recycling. The most common mRNA contains 4 coding exons, and it has 2 additional alternatively spliced exons.^[5] QNG1 has been found in 5 different splice variants.^[7]

AliasesQNG1, chromosome 9 open reading frame 64, C9orf64, Q-Nucleotide N-Glycosylase 1, Queuine Salvage Protein QNG1

External IDsOMIM: 611342; MGI: 1917403; GeneCards: QNG1

Chr.Chromosome 9 (human)^[1]

End83,956,986 bp^[1]

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QNG1
Identifiers
Aliases	QNG1, chromosome 9 open reading frame 64, C9orf64, Q-Nucleotide N-Glycosylase 1, Queuine Salvage Protein QNG1
External IDs	OMIM: 611342; MGI: 1917403; GeneCards: QNG1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.32 Start 83,938,311 bp[1] End 83,956,986 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 58,527,631 bp[2] End 58,533,039 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell skin of arm renal medulla nipple pylorus cardia trigeminal ganglion sperm ventral tegmental area superior surface of tongue Top expressed in ileum jejunum intestinal villus epithelium of small intestine vestibular membrane of cochlear duct endocardial cushion Ileal epithelium endothelial cell of lymphatic vessel lacrimal gland left colon More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component cellular component Biological process tRNA modification biological process tRNA-guanine transglycosylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 84267 70153 Ensembl ENSG00000165118 ENSMUSG00000021550 UniProt Q5T6V5 G3X8U3 RefSeq (mRNA) NM_032307 NM_001317997 NM_027335 RefSeq (protein) NP_001304926 NP_115683 NP_081611 Location (UCSC) Chr 9: 83.94 – 83.96 Mb Chr 13: 58.53 – 58.53 Mb PubMed search [3] [4]
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Expression of this gene is highest in the duodenum and small intestine, and it is also expressed in 24 other tissues.^[8]