QX39

CAS Number

• 1798331-71-1

PubChem CID

• 91809172

CompTox Dashboard (EPA)

• DTXSID101336839

FormulaC₂₀H₁₄ClNO

QX39

Identifiers
IUPAC name N-(4-(6-chloroquinoxalin-2-yl)phenyl)acetamide
CAS Number	1798331-71-1
PubChem CID	91809172
CompTox Dashboard (EPA)	DTXSID101336839
Chemical and physical data
Formula	C20H14ClNO
Molar mass	319.79 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1C(=NC2=C(O1)C=C(C=C2)Cl)C3=CC=C(C=C3)C4=CC=CC=C4
InChI InChI=1S/C20H14ClNO/c21-17-10-11-18-20(12-17)23-13-19(22-18)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-12H,13H2 Key:RJFBVAUZKPHMJI-UHFFFAOYSA-N

QX39 (Compound A, CA39) is a synthetic compound that activates chaperone-mediated autophagy (CMA) by increasing the expression of the lysosomal receptor for this pathway, LAMP2A lysosomes. It showed potent activity in vitro but has poor pharmacokinetic properties and was not suitable for animal research. Subsequent research led to the development of CA77.1, a CMA activator suitable for in vivo use.^{[1][2][3][4][5]}