Queen bee acid

Queen bee acid (10-hydroxy-2-decenoic acid or 10-HDA) is a fatty acid found in royal jelly.^[1][2][3]

Quick facts Names, Identifiers ...

Queen bee acid

Names
Preferred IUPAC name (2E)-10-Hydroxydec-2-enoic acid
Other names 10-Hydroxy-2-decenoic acid Royal jelly acid
Identifiers
CAS Number	14113-05-4 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:78668
ChemSpider	4472163
MeSH	C055543
PubChem CID	5312738
UNII	76B519G7TJ Y
CompTox Dashboard (EPA)	DTXSID601045504 DTXSID50997870, DTXSID601045504
InChI InChI=1S/C10H18O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h6,8,11H,1-5,7,9H2,(H,12,13)/b8-6+ Key: QHBZHVUGQROELI-SOFGYWHQSA-N InChI=1/C10H18O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h6,8,11H,1-5,7,9H2,(H,12,13)/b8-6+ Key: QHBZHVUGQROELI-SOFGYWHQBH
SMILES C(CCC/C=C/C(=O)O)CCCO
Properties
Chemical formula	C10H18O3
Molar mass	186.251 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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Queen bee acid is being investigated for its potential pharmacological activities. It promotes neurogenesis of neural stem/progenitor cells (cells capable of differentiating into neurons, astrocytes, or oligodendrocytes) in vitro.^[4] In addition, queen bee acid has been reported to have in vitro anti-tumor, anti-biotic, immunomodulatory, estrogenic, neurogenic, and innate immune response modulating activities.^[5]

In the United States, the Food and Drug Administration has taken legal action against companies that have used unfounded claims of health benefits to market royal jelly products.^[6][7]