Quinupramine
Tricyclic antidepressant
From Wikipedia, the free encyclopedia
Quinupramine (brand names Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.[1][2]
- In general: ℞ (Prescription only)
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| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Elimination half-life | 33 hours |
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| ECHA InfoCard | 100.046.149 |
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| Formula | C21H24N2 |
| Molar mass | 304.437 g·mol−1 |
Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor.[3] It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or D2 receptor.[3]
Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline.[4] It can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself.[citation needed]
