R-spondin 3
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene.[5][6][7]
External IDsOMIM: 610574; MGI: 1920030; HomoloGene: 12484; GeneCards: RSPO3; OMA:RSPO3 - orthologs
Function
This gene encodes a member of the thrombospondin type 1 repeat gene superfamily. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.[7]
During embryonic development, RSPO3 is expressed in the tail bud and the posterior presomitic mesoderm of the embryo. In tissue engineering, R-spondin 3 has been used to differentiate pluripotent stem cells into paraxial mesoderm progenitors[8]