R-spondin 3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene.[5][6][7]

AliasesRSPO3, CRISTIN1, PWTSR, THSD2, R-spondin 3
End127,199,481 bp[1]
Quick facts RSPO3, Identifiers ...
RSPO3
Identifiers
AliasesRSPO3, CRISTIN1, PWTSR, THSD2, R-spondin 3
External IDsOMIM: 610574; MGI: 1920030; HomoloGene: 12484; GeneCards: RSPO3; OMA:RSPO3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032784

NM_028351

RefSeq (protein)

NP_116173

NP_082627

Location (UCSC)Chr 6: 127.12 – 127.2 MbChr 10: 29.33 – 29.41 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the thrombospondin type 1 repeat gene superfamily. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.[7]

During embryonic development, RSPO3 is expressed in the tail bud and the posterior presomitic mesoderm of the embryo. In tissue engineering, R-spondin 3 has been used to differentiate pluripotent stem cells into paraxial mesoderm progenitors[8]

References

Further reading

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