RAET1L
From Wikipedia, the free encyclopedia
Retinoic acid early transcript 1L (RAET1L) is a cell surface glycoprotein encoded by RAET1L gene located on the chromosome 6.[1] RAET1L is related to MHC class I molecules, but its gene maps outside the MHC locus.[1] RAET1L is composed of the α1α2 domain and is linked to the cell membrane by the GPI anchor.[1][2] It functions as a stress-induced ligand for NKG2D receptor.[2] Its expression is, for example, triggered in course of HCMV infection, but HCMV alters its function.[2] HCMV-encoded UL16 glycoprotein retains ULBP6 inside the cells, preventing it from reaching the cell surface and being exposed to cells of the immune system.[2]
