RALY

RNA-binding protein Raly is a protein that in humans is encoded by the RALY gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesRALY, HNRPCL2, P542, RALY heterogeneous nuclear ribonucleoprotein

External IDsOMIM: 614663; MGI: 97850; HomoloGene: 7216; GeneCards: RALY; OMA:RALY - orthologs

Chr.Chromosome 20 (human)^[1]

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RALY
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WF1
Identifiers
Aliases	RALY, HNRPCL2, P542, RALY heterogeneous nuclear ribonucleoprotein
External IDs	OMIM: 614663; MGI: 97850; HomoloGene: 7216; GeneCards: RALY; OMA:RALY - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 33,993,646 bp[1] End 34,108,308 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H1|2 76.83 cM Start 154,633,016 bp[2] End 154,709,181 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence granulocyte ventricular zone right lobe of thyroid gland mucosa of transverse colon left lobe of thyroid gland left testis right testis ascending aorta popliteal artery Top expressed in neural layer of retina ventricular zone yolk sac granulocyte lip embryo epiblast tail of embryo embryo thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding transcription coregulator activity RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleus Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing regulation of transcription, DNA-templated transcription, DNA-templated regulation of nucleic acid-templated transcription cholesterol homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22913 19383 Ensembl ENSG00000125970 ENSMUSG00000027593 UniProt Q9UKM9 Q64012 RefSeq (mRNA) NM_007367 NM_016732 NM_001139511 NM_001139512 NM_001139513 NM_023130 RefSeq (protein) NP_031393 NP_057951 NP_001132983 NP_001132984 NP_001132985 NP_075619 Location (UCSC) Chr 20: 33.99 – 34.11 Mb Chr 2: 154.63 – 154.71 Mb PubMed search [3] [4]
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In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.^[6]