RANBP1

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.^[5][6][7]

AliasesRANBP1, HTF9A, RAN binding protein 1

External IDsOMIM: 601180; MGI: 96269; GeneCards: RANBP1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 22 (human)^[1]

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RANBP1
Identifiers
Aliases	RANBP1, HTF9A, RAN binding protein 1
External IDs	OMIM: 601180; MGI: 96269; GeneCards: RANBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K5D, 1K5G
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 20,115,938 bp[1] End 20,127,355 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 11.3 cM Start 18,057,648 bp[2] End 18,066,596 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone left testis right testis mucosa of transverse colon prefrontal cortex cerebellar hemisphere anterior cingulate cortex right hemisphere of cerebellum left uterine tube Top expressed in yolk sac epiblast embryo tail of embryo embryo genital tubercle ventricular zone neural tube mesencephalon ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity GDP-dissociation inhibitor activity protein binding cadherin binding Cellular component cytoplasm nuclear envelope nucleus centrosome cytosol nuclear pore Biological process positive regulation of GTPase activity intracellular transport viral process signal transduction ubiquitin-dependent protein catabolic process regulation of catalytic activity protein import into nucleus spindle organization positive regulation of mitotic centrosome separation RNA export from nucleus G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 5902 19385 Ensembl ENSG00000099901 ENSMUSG00000005732 UniProt P43487 P34022 RefSeq (mRNA) NM_001278639 NM_001278640 NM_001278641 NM_002882 NM_011239 RefSeq (protein) NP_001265568 NP_001265569 NP_001265570 NP_002873 NP_035369 Location (UCSC) Chr 22: 20.12 – 20.13 Mb Chr 16: 18.06 – 18.07 Mb PubMed search [3] [4]
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Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RANGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.^[7]