RASGRF2

RASGRF2
Identifiers
Aliases	RASGRF2, GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2
External IDs	OMIM: 606614; MGI: 109137; HomoloGene: 2169; GeneCards: RASGRF2; OMA:RASGRF2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	81,230,162 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	92,268,164 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; sural nerve; ; Brodmann area 46; ; prefrontal cortex; ; corpus callosum; ; superior frontal gyrus; ; C1 segment; ; occipital lobe;
	Top expressed in
	ventromedial nucleus; ; olfactory tubercle; ; neural layer of retina; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; substantia nigra; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	calmodulin binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; plasma membrane; endoplasmic reticulum;
Biological process	regulation of Ras protein signal transduction; MAPK cascade; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; response to endoplasmic reticulum stress; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5924
	19418
	ENSG00000113319
	ENSMUSG00000021708
	O14827
	P70392
	NM_006909
	NM_009027
	NP_008840
	NP_033053
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.^[5]

AliasesRASGRF2, GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2

External IDsOMIM: 606614; MGI: 109137; HomoloGene: 2169; GeneCards: RASGRF2; OMA:RASGRF2 - orthologs

Chr.Chromosome 5 (human)^[1]

End81,230,162 bp^[1]

Quick facts Identifiers, Aliases ...

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RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM]^[5]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.^[6]

[5]

[1]

[2]

[3]

[4]

[6]

RASGRF2

References

Further reading

Related Articles

Related Articles

"Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras"

"Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"Large-scale mapping of human protein-protein interactions by mass spectrometry"

"RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses"