RBX1

RBX1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1LDJ, 1LDK, 1U6G, 2HYE, 2LGV, 3DPL, 3DQV, 3RTR, 4F52, 4P5O
Identifiers
Aliases	RBX1, BA554C12.1, RNF75, ROC1, ring-box 1
External IDs	OMIM: 603814; MGI: 3710517; HomoloGene: 6872; GeneCards: RBX1; OMA:RBX1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	40,973,309 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; trabecular bone; ; Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; monocyte; ; palpebral conjunctiva; ; beta cell; ; C1 segment; ; olfactory bulb; ; oral cavity;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cullin family protein binding; ubiquitin protein ligase activity; zinc ion binding; metal ion binding; ubiquitin-ubiquitin ligase activity; protein binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; NEDD8 transferase activity; transcription factor binding; transferase activity; protein-containing complex binding;
Cellular component	cytoplasm; cullin-RING ubiquitin ligase complex; cytosol; SCF ubiquitin ligase complex; VCB complex; Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; Cul7-RING ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; Cul4B-RING E3 ubiquitin ligase complex; nucleus; nucleoplasm; nuclear SCF ubiquitin ligase complex; Cul4-RING E3 ubiquitin ligase complex;
Biological process	nucleotide-excision repair, DNA damage recognition; protein monoubiquitination; MAPK cascade; cellular response to DNA damage stimulus; protein neddylation; global genome nucleotide-excision repair; protein catabolic process; regulation of transcription from RNA polymerase II promoter in response to hypoxia; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; negative regulation of canonical Wnt signaling pathway; nucleotide-excision repair, preincision complex stabilization; DNA repair; viral process; protein polyubiquitination; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA incision, 5'-to lesion; Wnt signaling pathway; SCF complex assembly; negative regulation of G2/M transition of mitotic cell cycle; post-translational protein modification; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; interleukin-1-mediated signaling pathway; protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision, 3'-to lesion;
	Sources:Amigo / QuickGO
Orthologs
	9978
	100043674
	ENSG00000100387
	n/a
	P62877
	n/a
	NM_014248
	XM_006525232; XM_006536722; XM_006537452
	NP_055063
	n/a
	Wikidata
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