REV1

DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesREV1, REV1L, AIBP80, DNA directed polymerase, REV1 DNA directed polymerase

External IDsOMIM: 606134; MGI: 1929074; HomoloGene: 32309; GeneCards: REV1; OMA:REV1 - orthologs

Chr.Chromosome 2 (human)^[1]

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REV1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBW, 2LSI, 2LSK, 2LSY, 3GQC, 3VU7, 4BA9, 4EXT, 4GK0, 4GK5, 2N1G
Identifiers
Aliases	REV1, REV1L, AIBP80, DNA directed polymerase, REV1 DNA directed polymerase
External IDs	OMIM: 606134; MGI: 1929074; HomoloGene: 32309; GeneCards: REV1; OMA:REV1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 99,400,475 bp[1] End 99,490,035 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 38,052,786 bp[2] End 38,129,801 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon cerebellar hemisphere right hemisphere of cerebellum right uterine tube ectocervix gastric mucosa body of uterus skin of abdomen left ovary Top expressed in zygote secondary oocyte tail of embryo superior cervical ganglion Rostral migratory stream spermatocyte lobe of cerebellum cerebellar vermis primary oocyte otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity damaged DNA binding DNA binding nucleotidyltransferase activity protein binding metal ion binding deoxycytidyl transferase activity Cellular component nucleus nucleoplasm Biological process DNA replication translesion synthesis DNA biosynthetic process response to UV error-prone translesion synthesis cellular response to DNA damage stimulus DNA repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51455 56210 Ensembl ENSG00000135945 ENSMUSG00000026082 UniProt Q9UBZ9 Q920Q2 RefSeq (mRNA) NM_001037872 NM_016316 NM_001321454 NM_001321455 NM_001321458 NM_001321459 NM_001321460 NM_019570 NM_001359287 NM_001359288 RefSeq (protein) NP_001032961 NP_001308383 NP_001308384 NP_001308387 NP_001308388 NP_001308389 NP_057400 NP_062516 NP_001346216 NP_001346217 Location (UCSC) Chr 2: 99.4 – 99.49 Mb Chr 1: 38.05 – 38.13 Mb PubMed search [3] [4]
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This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.^[6]

Rev1 is a Y family DNA polymerase; it is sometimes referred to as a deoxycytidyl transferase because it only inserts deoxycytidine (dC) across from lesions. Whether G, A, T, C, or an abasic site, Rev1 will always add a C. Rev1 has the ability to always add a C, because it uses an arginine as a template which complements well with C.^[7] Yet it is believed^{[by whom?]} that Rev1 rarely uses its polymerase activity; rather it is thought that Rev1's primary role is as a protein landing pad, whereby it helps direct the recruitment of TLS proteins, especially Pol ζ (Rev3/Rev7).