RF3286

RF3286
Identifiers
	IUPAC name (2S)-2-[[(2R)-5-(diaminomethylideneamino)-2-(3,3-diphenylprop-2-enoylamino)pentanoyl]amino]-4-methylpentanamide;
PubChem CID	166631924;
ChemSpider	129298592;
ChEMBL	ChEMBL5085324;
Chemical and physical data
Formula	C27H36N6O3
Molar mass	492.624 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C[C@@H](C(=O)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)C=C(C1=CC=CC=C1)C2=CC=CC=C2;
	InChI InChI=1S/C27H36N6O3/c1-18(2)16-23(25(28)35)33-26(36)22(14-9-15-31-27(29)30)32-24(34)17-21(19-10-5-3-6-11-19)20-12-7-4-8-13-20/h3-8,10-13,17-18,22-23H,9,14-16H2,1-2H3,(H2,28,35)(H,32,34)(H,33,36)(H4,29,30,31)/t22-,23+/m1/s1; Key:DHCKIFBNEHPVAG-PKTZIBPZSA-N;

RF3286 is a drug used in scientific research which acts as a potent and selective antagonist for the neuropeptide FF receptor NPFF1. Unlike the older compound RF9 it shows good selectivity over the closely related NPFF2 subtype, as well as over other related receptor targets such as neuropeptide Y receptors. In animal studies, RF3286 potently inhibited the development of hyperalgesia produced by mu-opioid agonists while also increasing analgesia.^[1]^[2]

PubChem CID

166631924

ChemSpider

129298592

ChEMBL

ChEMBL5085324

FormulaC₂₇H₃₆N₆O₃

Quick facts Identifiers, PubChem CID ...

Close

[1]

[2]

RF3286

References

Related Articles

Identifiers

IUPAC name (2S)-2-[[(2R)-5-(diaminomethylideneamino)-2-(3,3-diphenylprop-2-enoylamino)pentanoyl]amino]-4-methylpentanamide
PubChem CID	166631924
ChemSpider	129298592
ChEMBL	ChEMBL5085324
Chemical and physical data
Formula	C₂₇H₃₆N₆O₃
Molar mass	492.624 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)C[C@@H](C(=O)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)C=C(C1=CC=CC=C1)C2=CC=CC=C2
InChI InChI=1S/C27H36N6O3/c1-18(2)16-23(25(28)35)33-26(36)22(14-9-15-31-27(29)30)32-24(34)17-21(19-10-5-3-6-11-19)20-12-7-4-8-13-20/h3-8,10-13,17-18,22-23H,9,14-16H2,1-2H3,(H2,28,35)(H,32,34)(H,33,36)(H4,29,30,31)/t22-,23+/m1/s1 Key:DHCKIFBNEHPVAG-PKTZIBPZSA-N