RIC3

RIC3
Identifiers
Aliases	RIC3, AYST720, PRO1385, RIC3 acetylcholine receptor chaperone, RIC-3
External IDs	OMIM: 610509; MGI: 2443887; HomoloGene: 49772; GeneCards: RIC3; OMA:RIC3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	8,169,055 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	108,682,538 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; body of pancreas; ; right uterine tube; ; left ovary; ; gastric mucosa; ; skin of abdomen; ; minor salivary glands;
	Top expressed in
	Rostral migratory stream; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; visual cortex; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; superior frontal gyrus; ; spermatocyte; ; cerebellar cortex; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein folding chaperone activity; acetylcholine receptor binding;
Cellular component	integral component of membrane; neuron projection; Golgi membrane; soma; Golgi apparatus; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; synaptic transmission, cholinergic; protein localization to cell surface; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	79608
	320360
	ENSG00000166405
	ENSMUSG00000048330
	Q7Z5B4
	Q8BPM6
NM_001135109; NM_001206671; NM_001206672; NM_024557; NM_001346690;
	NM_001346691; NM_001346692; NM_001346693; NM_001346694
	NM_001038624; NM_178780; NM_001311161
NP_001128581; NP_001193600; NP_001193601; NP_001333619; NP_001333620;
	NP_001333621; NP_001333622; NP_001333623; NP_078833
	NP_001033713; NP_001298090; NP_848895
	Wikidata
View/Edit Human	View/Edit Mouse

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.^[5] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT₃ receptor and nicotinic acetylcholine receptors,^[6]^[7] particularly the homomeric α₇ nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.^[8]