RNF135

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.^[5][6][7]

AliasesRNF135, MMFD, REUL, Riplet, L13, ring finger protein 135

External IDsOMIM: 611358; MGI: 1919206; HomoloGene: 12427; GeneCards: RNF135; OMA:RNF135 - orthologs

Chr.Chromosome 17 (human)^[1]

End30,999,911 bp^[1]

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RNF135
Identifiers
Aliases	RNF135, MMFD, REUL, Riplet, L13, ring finger protein 135
External IDs	OMIM: 611358; MGI: 1919206; HomoloGene: 12427; GeneCards: RNF135; OMA:RNF135 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 30,970,984 bp[1] End 30,999,911 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 47.59 cM Start 80,074,677 bp[2] End 80,090,583 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell parietal pleura synovial membrane visceral pleura skin of arm mucosa of ileum secondary oocyte gingival epithelium human penis synovial joint Top expressed in proximal tubule right kidney epithelium of small intestine granulocyte interventricular septum utricle left lobe of liver spleen lacrimal gland ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function ribonucleoprotein complex binding protein binding metal ion binding ubiquitin-protein transferase activity identical protein binding transferase activity Cellular component cytoplasm cytosol Biological process positive regulation of interferon-beta production negative regulation of type I interferon production innate immune response regulation of innate immune response protein ubiquitination immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84282 71956 Ensembl ENSG00000181481 ENSMUSG00000020707 UniProt Q8IUD6 Q9CWS1 RefSeq (mRNA) NM_001184992 NM_032322 NM_197939 NM_028019 RefSeq (protein) NP_001171921 NP_115698 NP_922921 NP_082295 Location (UCSC) Chr 17: 30.97 – 31 Mb Chr 11: 80.07 – 80.09 Mb PubMed search [3] [4]
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The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]