ROD-188

ROD-188
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name (5R)-5-{(1R)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}dihydrofuran-2(3H)-one;
CAS Number	309267-40-1 ;
PubChem CID	9842377;
ChemSpider	8018092;
ChEMBL	ChEMBL136324;
CompTox Dashboard (EPA)	DTXSID001027550 ;
Chemical and physical data
Formula	C20H21NO4S
Molar mass	371.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc(cc1)S(=O)(=O)N2CCc4ccccc4[C@@H]2[C@@H]3CCC(=O)O3;
	(verify)

ROD-188 is a sedative drug that was structurally derived from the GABA_A antagonist bicuculline by a team at Roche.^[1] Unlike bicuculline, ROD-188 acts as an agonist at GABA_A receptors, being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines, barbiturates or muscimol, with its strongest effect produced at the α6β2γ2 subtype of the GABA_A receptor.^[2] ROD-188 is one of a number of related compounds acting at this novel modulatory site, some of which also act at benzodiazepine receptors.^[3]^[4]