RTI-122

RTI-122
Identifiers
	IUPAC name (1R,2R)-N-[(2R,3R)-2-amino-3-methoxybutyl]-2-(5-fluoropyridin-2-yl)-N-[4-(4-propan-2-yloxyphenyl)phenyl]cyclopropane-1-carboxamide;
CAS Number	3034664-39-3;
PubChem CID	167993640;
ChemSpider	129307012;
ChEMBL	ChEMBL5498825;
Chemical and physical data
Formula	C29H34FN3O3
Molar mass	491.607 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]([C@@H](CN(C1=CC=C(C=C1)C2=CC=C(C=C2)OC(C)C)C(=O)[C@@H]3C[C@H]3C4=NC=C(C=C4)F)N)OC;
	InChI InChI=1S/C29H34FN3O3/c1-18(2)36-24-12-7-21(8-13-24)20-5-10-23(11-6-20)33(17-27(31)19(3)35-4)29(34)26-15-25(26)28-14-9-22(30)16-32-28/h5-14,16,18-19,25-27H,15,17,31H2,1-4H3/t19-,25-,26-,27-/m1/s1; Key:OXODNABCLPQQDT-CEWWTIOHSA-N;

RTI-122 is an experimental drug which acts as a selective agonist for the receptor GPR88, with improved stability and brain penetration compared to older ligands. This receptor is poorly characterised and the development of selective ligands is important for researching its function in the body. In tests on rats, RTI-122 was found to reduce alcohol consumption, suggesting a role for GPR88 in the reward system.^[1]

CAS Number

3034664-39-3

PubChem CID

167993640

ChemSpider

129307012

ChEMBL

ChEMBL5498825

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RTI-122

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Identifiers

IUPAC name (1R,2R)-N-[(2R,3R)-2-amino-3-methoxybutyl]-2-(5-fluoropyridin-2-yl)-N-[4-(4-propan-2-yloxyphenyl)phenyl]cyclopropane-1-carboxamide
CAS Number	3034664-39-3
PubChem CID	167993640
ChemSpider	129307012
ChEMBL	ChEMBL5498825
Chemical and physical data
Formula	C₂₉H₃₄FN₃O₃
Molar mass	491.607 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@H]([C@@H](CN(C1=CC=C(C=C1)C2=CC=C(C=C2)OC(C)C)C(=O)[C@@H]3C[C@H]3C4=NC=C(C=C4)F)N)OC
InChI InChI=1S/C29H34FN3O3/c1-18(2)36-24-12-7-21(8-13-24)20-5-10-23(11-6-20)33(17-27(31)19(3)35-4)29(34)26-15-25(26)28-14-9-22(30)16-32-28/h5-14,16,18-19,25-27H,15,17,31H2,1-4H3/t19-,25-,26-,27-/m1/s1 Key:OXODNABCLPQQDT-CEWWTIOHSA-N