RU-1205

RU-1205 is a kappa opioid receptor agonist used for pain treatment. It has high bioavailability (44.17 and 56.03% upon peroral and subcutaneous introduction).^[1]

CAS Number

• 849034-26-0 ^Y

PubChem CID

• 4641302

ChemSpider

• 3831213

FormulaC₂₁H₂₁FN₄O

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RU-1205

Identifiers
IUPAC name 4-[2-[2-(4-fluorophenyl)imidazo[1,2-a]benzimidazol-4-yl]ethyl]morpholine
CAS Number	849034-26-0 Y
PubChem CID	4641302
ChemSpider	3831213
Chemical and physical data
Formula	C21H21FN4O
Molar mass	364.424 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1COCCN1CCN2C3=CC=CC=C3N4C2=NC(=C4)C5=CC=C(C=C5)F
InChI InChI=1S/C21H21FN4O/c22-17-7-5-16(6-8-17)18-15-26-20-4-2-1-3-19(20)25(21(26)23-18)10-9-24-11-13-27-14-12-24/h1-8,15H,9-14H2 Key:VRTSZUQZRYFXJK-UHFFFAOYSA-N

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Granulated RU-1205 produced maximum analgesic effect within 4-h investigation and retained higher analgesic activity compared to that of parent substance.^[2]

RU-1205 does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.^[3]