Raclopride

Raclopride is a typical antipsychotic. It acts as a selective antagonist on D₂ dopamine receptors.^[1] It has been used in trials studying Parkinson Disease.^[2]

ATC code

• none

CAS Number

• 84225-95-6

PubChem CID

• 3033769

IUPHAR/BPS

• 94

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Raclopride

Clinical data
ATC code	none
Identifiers
IUPAC name 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
CAS Number	84225-95-6
PubChem CID	3033769
IUPHAR/BPS	94
ChemSpider	2298373
UNII	430K3SOZ7G
KEGG	D82063
ChEBI	CHEBI:92070
ChEMBL	ChEMBL8809
CompTox Dashboard (EPA)	DTXSID9045687
Chemical and physical data
Formula	C15H20Cl2N2O3
Molar mass	347.24 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1c(O)c(c(OC)c(Cl)c1)C(=O)NC[C@H]2N(CC)CCC2
InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 Y Key:WAOQONBSWFLFPE-VIFPVBQESA-N Y
NY (what is this?)  (verify)

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Raclopride is selective for D2 and D3 dopamine receptors.^[3]

It can be radiolabelled with radioisotopes, e.g. ³H or ¹¹C and used as a tracer for in vitro imaging (autoradiography) as well as in vivo imaging positron emission tomography (PET). Images obtained by cerebral PET scanning (e.g. PET/CT or PET/MRI) allow the non-invasive assessment of the binding capacity of the cerebral D₂ dopamine receptor, which can be useful for the diagnosis of movement disorders. In particular, cerebral D₂ receptor binding as measured by carbon-11-raclopride (¹¹C-raclopride) has shown to reflect disease severity of Huntington's disease, a genetic disease characterized by selective degeneration of cerebral D₂ receptors.^[4]

Other studies have investigated the relationship of D₂ receptor binding capacity and personality disorders. One study found decreased binding in the detachment personality trait.^[5] Radiolabelled raclopride is also commonly used to determine the efficacy and neurotoxicity of dopaminergic drugs.