Radiation sensitivity index
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The radiation sensitivity index (RSI) is a gene-expression–based model developed to estimate the intrinsic radiosensitivity of tumor cells. RSI was created by correlating cancer cell line survival after ionizing radiation with baseline gene-expression patterns, identifying a set of genes predictive of cellular response to radiation.[1]
RSI has been evaluated across multiple cancer types and clinical cohorts, and serves as the genomic basis of the genomic adjusted radiation dose (GARD), a framework integrating radiosensitivity with the linear–quadratic model to estimate the biological effect of a given radiation dose.[2]