Refractory cytopenia of childhood
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| Refractory cytopenia of childhood | |
|---|---|
| Other names | RCC |
Refractory cytopenia of childhood is a subgroup of myelodysplastic syndrome (MDS), having been added to the World Health Organization classification in 2008. Before then, RCC cases were classified as childhood aplastic anemia.[1][2] RCC is the most common form of MDS in children and adolescents, accounting for approximately half of all MDS cases.[3]
Symptoms result from underproduction of red blood cells (weakness, pallor, failure to thrive, pica), white blood cells (recurrent or overwhelming infection), and/or platelets (bleeding).[citation needed]
Histopathologic features
The bone marrow of patients with RCC contains islands of erythroid precursors and spare granulocytes. In some scenarios, multiple bone marrow biopsy examinations may be recommended before a diagnosis can be established.[citation needed]
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