Wyatt was born in London, the son of Edward Wyatt (1757–1833) and his wife, Anne Maddox. He was baptised at St James, Middlesex. He studied at the Royal Academy Schools, where he gained two medals, and served his apprenticeship with John Charles Felix Rossi.
In 1818 he exhibited at the Royal Academy a piece entitled the Judgment of Paris, and in 1819 a monument to Lady Anne Hudson; other early memorial works by him are in Esher church and St. John's Wood chapel. When Canova visited this country Wyatt was brought under his notice by Sir Thomas Lawrence, and received from him an invitation to Rome. He left England early in 1821, and, after studying for a few months in Paris under Bosio, proceeded to Rome, and entered the studio of Canova, where he had John Gibson (1790–1866) as a fellow pupil.
Settling permanently in Rome, Wyatt practised his profession there with great enthusiasm and success, and from 1831 until his death was a frequent exhibitor at the Royal Academy. Among his best works were Ino and the infant Bacchus, Girl at the Bath, Musidora (at Chatsworth), and Penelope, The Huntress, and Flora (all in the royal collection). Several of these have been engraved for The Art Journal. The ‘Penelope’ was a commission given by the queen to Wyatt at the time of his only visit to England in 1841. Wyatt was a highly accomplished artist, particularly excelling in his female figures, which in purity of form and beauty of line rivalled those of his master Canova. A woodcut portrait, from a drawing by S. Pearce, accompanies a memoir of him in The Art Journal, published in 1850.
Versions of his Ino and the infant Bacchus are at the Fitzwilliam Museum, Cambridge and another formerly at County Hall Chester.
