Calvo trained as a teacher and has a degree in Philosophy and Educational Sciences and a higher degree in Sociology of Education. She worked as a teacher and director of her order's centre in Zaragoza and was a founder and president of the Barró Association in Madrid, which works with people at risk of exclusion. She was a member of the Board of Trustees of the Company of Mary International Solidarity Foundation (FISC), and later the president. [4] From 1994 to 2003 she was part of the leadership team of the Spanish branch of her order, and from 2003 part of the general (international) governance of the order.[3]
On 27 July 2015 she was named Superior General of Sisters of the Company of Mary, Our Lady.[5][6] She was re-elected in April 2022 for a six-year term.[3][7]
In 2019 she was appointed as one of the first women to the Congregation for Institutes of Consecrated Life and Societies of Apostolic Life. The other women were Kathleen Appler, Yvonne Reungoat, Françoise Massy, Luigia Coccia, Simona Brambilla and Olga Krizova.[1]