Roman Zubarev
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Roman A. Zubarev | |
|---|---|
 | |
| Born | 1963 (age 62–63) |
| Alma mater | Moscow Engineering Physics Institute; Uppsala University |
| Known for | Electron-capture dissociation; Isotopic resonance hypothesis; Proteomics; Alzheimer’s disease research; Origin of life studies |
| Awards | Curt Brunnée Award (2006); Biemann Medal (2007); Gold Medal, Russian Mass Spectrometry Society (2013); Berzelius Medal in Gold (2024) |
| Scientific career | |
| Fields | Chemistry; Physics; Biochemistry; Proteomics |
| Institutions | Cornell University; University of Southern Denmark; Uppsala University; Karolinska Institutet |
| Doctoral advisor | Bo Sundqvist |
Roman A. Zubarev (born 1963) is a Russian-Swedish chemist and professor of medical proteomics in the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, Stockholm, Sweden. His research spans mass spectrometry, proteomics, origin-of-life chemistry, disease biomarker discovery, and related fields.[1]
Zubarev earned a Master of Science in Applied Physics at Moscow Engineering Physics Institute in 1986. He obtained a PhD in ion physics from Uppsala University in 1997, supervised by Bo Sundqvist.[2]
After his doctorate, he worked at Cornell University, where in 1997 he co-discovered electron-capture dissociation (ECD) of polypeptides with Fred McLafferty.[3] He later held posts at the University of Southern Denmark and Uppsala University, before becoming professor of medicinal proteomics at Karolinska Institutet.[1]
Research
Zubarev’s contributions include:
- Electron-capture dissociation (ECD) — A mass spectrometry fragmentation technique for sequencing proteins and peptides.[4]
- Isotopic resonance hypothesis — Proposes that specific isotopic compositions can accelerate biochemical reactions. Experimental studies on Escherichia coli growth have supported aspects of the hypothesis.[5]
- Proteomics and biomarkers — Discovery of proteomic signatures in neurodegenerative diseases such as Alzheimer’s disease, along with developments in immunoproteomics and molecular biometry.[6]
- Origin of life experiments — Research showing that abiotically synthesized mixtures, such as those produced in Miller–Urey type experiments, can sustain bacterial growth.[7]