Aguigui Reyes was born in Merizo in 1915,[1] the daughter of Bienvenida Mata Tyquiengco and Ignacio Babauta Aguigui.[2] She was educated at Agana High School,[2] and began teaching at Merizo Martyrs Elementary School in 1933.[1] In 1946 she married Ignacio Mendiola Reyes.[2]
After the liberation of Guam at the end of World War II, elections to the Guam Congress were held in July 1946. Aguigui Reyes was a successful candidate, becoming the first female member of the Congress.[2] She served for one term, after which she entered the new College of Guam, graduating in 1954 with an associate's degree in education.[2] She subsequently attended the University of Hawaiʻi and continued working as a teacher at Merizo Martyrs Elementary School, where she stayed for 31 years.[2] She also served as principal of F. Q. Sanchez School in Umatac for eleven years.[1]
She died on 29 January 2007 aged 91.[1] The library in Merizo was named the Rosa Aguigui Reyes Memorial Library after her.[2]