Ezetimibe/rosuvastatin
Cholesterol medication
From Wikipedia, the free encyclopedia
Ezetimibe/rosuvastatin, sold under the brand name Ridutrin among others, is a combination medication used to treat high cholesterol.[6][7] In some countries it is sold as a kit or a pack containing two distinct pills.[8][9]
Trade namesRidutrink, Roszet, others
Ezetimibe (top) and rosuvastatin (bottom) | |
| Combination of | |
|---|---|
| Ezetimibe | Hypolipidemic agent |
| Rosuvastatin | Statin |
| Clinical data | |
| Trade names | Ridutrink, Roszet, others |
| AHFS/Drugs.com | Multum Consumer Information |
| License data | |
| Pregnancy category |
|
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| KEGG | |
The combination was approved for medical use in the United States in March 2021.[4]
Medical uses
Ezetimibe/rosuvastatin is indicated as an adjunct to diet in people with primary non-familial hyperlipidemia to reduce low-density lipoprotein cholesterol (LDL-C); and alone or as an adjunct to other LDL-C-lowering therapies in people with homozygous familial hypercholesterolemia (HoFH) to reduce LDL-C.[10]
Pharmacology
Ezetimibe/rosuvastatin combines two lipid-lowering therapies.
- Ezetimibe inhibits NPC1L1, the transporter that is responsible for absorption of dietary cholesterol from the intestine.[3]
- Rosuvastatin inhibits HMG-CoA reductase, an enzyme involved in synthesis of new cholesterol in the liver.[3]
