Rupintrivir

Rupintrivir
Clinical data
Trade names	Rupintrivir
Legal status
Legal status	US: Investigational drug;
Identifiers
	IUPAC name Ethyl (E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazole-3-carbonyl)amino]-4-oxoheptanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate;
CAS Number	223537-30-2;
PubChem CID	6440352;
DrugBank	05102;
ChemSpider	4944627;
UNII	RGE5K1Q5QW;
KEGG	D05776;
ChEMBL	ChEMBL20210;
Chemical and physical data
Formula	C31H39FN4O7
Molar mass	598.672 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC(=O)/C=C/[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC2=CC=C(C=C2)F)CC(=O)[C@H](C(C)C)NC(=O)C3=NOC(=C3)C;
	InChI InChI=1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1; Key:CAYJBRBGZBCZKO-BHGBQCOSSA-N;

Rupintrivir (AG-7088, Rupinavir) is a peptidomimetic antiviral drug which acts as a 3C and 3CL protease inhibitor.^[1]^[2]^[3] It was developed for the treatment of rhinoviruses,^[4]^[5] and has subsequently been investigated for the treatment of other viral diseases including those caused by picornaviruses,^[6]^[7] norovirus,^[8] and coronaviruses, such as SARS and COVID-19.^[9]^[10]