SAM-IV riboswitch
From Wikipedia, the free encyclopedia
| S-adenosyl methionine (SAM) riboswitch, | |
|---|---|
 Predicted secondary structure and sequence conservation of SAM-IV | |
| Identifiers | |
| Symbol | SAM-IV |
| Rfam | RF00634 CL00012 |
| Other data | |
| RNA type | Cis-reg; riboswitch |
| Domain(s) | Bacteria |
| SO | SO:0005836 |
| PDB structures | PDBe |
SAM-IV riboswitches are a kind of riboswitch that specifically binds S-adenosylmethionine (SAM),[1] a cofactor used in many methylation reactions. Originally identified by bioinformatics,[2] SAM-IV riboswitches are largely confined to the Actinomycetales, an order of Bacteria. Conserved features of SAM-IV riboswitch and experiments imply that they probably share a similar SAM-binding site to another class of SAM-binding riboswitches called SAM-I riboswitches. However, the scaffolds of these two types of riboswitch appear to be quite distinct. The structural relationship between these riboswitch types has been studied.[3][4]
