SB-399885

SB-399885
Identifiers
	IUPAC name N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide;
CAS Number	402713-80-8 ;
PubChem CID	6918649;
IUPHAR/BPS	3241;
ChemSpider	5293842;
UNII	5BH7TN3FWY;
ChEMBL	ChEMBL1210710 ;
CompTox Dashboard (EPA)	DTXSID60437717 ;
Chemical and physical data
Formula	C18H21Cl2N3O4S
Molar mass	446.34 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C3CNCCN3c2cc(ccc2OC)S(=O)(=O)Nc(c1OC)cc(Cl)cc1Cl;
	InChI InChI=1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3; Key:ATKZKAYWARYLBW-UHFFFAOYSA-N;
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SB-399885 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆ receptor antagonist, with a Ki of 9.0nM. SB-399885 and other 5-HT₆ antagonists show nootropic effects in animal studies,^[1]^[2] as well as antidepressant and anxiolytic effects which are comparable to and synergistic with drugs such as imipramine and diazepam,^[3]^[4]^[5] and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia^[6] and Alzheimer's disease.

CAS Number

402713-80-8^Y

PubChem CID

6918649

IUPHAR/BPS

3241

ChemSpider

5293842

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SB-399885

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Identifiers

IUPAC name N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide
CAS Number	402713-80-8^Y
PubChem CID	6918649
IUPHAR/BPS	3241
ChemSpider	5293842
UNII	5BH7TN3FWY
ChEMBL	ChEMBL1210710^N
CompTox Dashboard (EPA)	DTXSID60437717
Chemical and physical data
Formula	C₁₈H₂₁Cl₂N₃O₄S
Molar mass	446.34 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C3CNCCN3c2cc(ccc2OC)S(=O)(=O)Nc(c1OC)cc(Cl)cc1Cl
InChI InChI=1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3 Key:ATKZKAYWARYLBW-UHFFFAOYSA-N
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