SB-408124

SB-408124
Identifiers
	IUPAC name 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea;
CAS Number	288150-92-5 ;
PubChem CID	4331799;
IUPHAR/BPS	1704;
ChemSpider	3536200 ;
UNII	C3YT74C744;
CompTox Dashboard (EPA)	DTXSID20402022 ;
ECHA InfoCard	100.164.461
Chemical and physical data
Formula	C19H18F2N4O
Molar mass	356.377 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3cc(N(C)C)ccc3NC(=O)Nc1cc(C)nc2c1cc(F)cc2F;
	InChI InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26) ; Key:JTARFZSNUAGHRB-UHFFFAOYSA-N ;
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SB-408124 is a drug which is a non-peptide antagonist selective for the orexin receptor subtype OX₁, with around 70x selectivity for OX₁ over OX₂ receptors, and improved oral bioavailability compared to the older OX₁ antagonist SB-334867. It is used in scientific research into the function of orexinergic neurons in the body.^[1]^[2]

CAS Number

288150-92-5^Y

PubChem CID

4331799

IUPHAR/BPS

1704

ChemSpider

3536200^N

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SB-408124

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Identifiers

IUPAC name 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea
CAS Number	288150-92-5^Y
PubChem CID	4331799
IUPHAR/BPS	1704
ChemSpider	3536200^N
UNII	C3YT74C744
CompTox Dashboard (EPA)	DTXSID20402022
ECHA InfoCard	100.164.461
Chemical and physical data
Formula	C₁₉H₁₈F₂N₄O
Molar mass	356.377 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c3cc(N(C)C)ccc3NC(=O)Nc1cc(C)nc2c1cc(F)cc2F
InChI InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26)^N Key:JTARFZSNUAGHRB-UHFFFAOYSA-N^N
^NY (what is this?) (verify)