SBI-115

SBI-115
Identifiers
	IUPAC name (3-methylphenyl) 5-chloro-2-ethylsulfonylpyrimidine-4-carboxylate;
CAS Number	882366-16-7;
PubChem CID	18879973;
ChemSpider	11981745;
Chemical and physical data
Formula	C14H13ClN2O4S
Molar mass	340.78 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCS(=O)(=O)C1=NC=C(C(=N1)C(=O)OC2=CC=CC(=C2)C)Cl;
	InChI InChI=1S/C14H13ClN2O4S/c1-3-22(19,20)14-16-8-11(15)12(17-14)13(18)21-10-6-4-5-9(2)7-10/h4-8H,3H2,1-2H3; Key:IJPXOPBVXVPPEW-UHFFFAOYSA-N;

SBI-115 is an experimental drug which acts as a potent and selective antagonist for the G protein-coupled bile acid receptor (GPBAR1/TGR5). It is used for studying the function of this receptor, and has been found to show beneficial effects in animal models of polycystic liver disease as well as some forms of cancer.^[1]^[2]^[3]^[4]^[5]

FormulaC₁₄H₁₃ClN₂O₄S

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Identifiers

IUPAC name (3-methylphenyl) 5-chloro-2-ethylsulfonylpyrimidine-4-carboxylate
CAS Number	882366-16-7
PubChem CID	18879973
ChemSpider	11981745
Chemical and physical data
Formula	C₁₄H₁₃ClN₂O₄S
Molar mass	340.78 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCS(=O)(=O)C1=NC=C(C(=N1)C(=O)OC2=CC=CC(=C2)C)Cl
InChI InChI=1S/C14H13ClN2O4S/c1-3-22(19,20)14-16-8-11(15)12(17-14)13(18)21-10-6-4-5-9(2)7-10/h4-8H,3H2,1-2H3 Key:IJPXOPBVXVPPEW-UHFFFAOYSA-N