SELENOS

Selenoprotein S, also known as SELS, is a human gene.^[5]

AliasesSELENOS, ADO15, SBBI8, SELS, SEPS1, AD-015, VIMP, VCP interacting membrane selenoprotein, selenoprotein S

External IDsOMIM: 607918; MGI: 95994; GeneCards: SELENOS

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 15 (human)^[1]

Quick facts Identifiers, Aliases ...

SELENOS
Identifiers
Aliases	SELENOS, ADO15, SBBI8, SELS, SEPS1, AD-015, VIMP, VCP interacting membrane selenoprotein, selenoprotein S
External IDs	OMIM: 607918; MGI: 95994; GeneCards: SELENOS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q2F
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.3 Start 101,270,817 bp[1] End 101,277,500 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 C|7 35.49 cM Start 65,729,397 bp[2] End 65,739,153 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum skin of arm myocardium of left ventricle mucosa of sigmoid colon jejunal mucosa cartilage tissue tibialis anterior muscle parotid gland rectum duodenum Top expressed in lacrimal gland seminal vesicula Epithelium of choroid plexus Paneth cell conjunctival fornix salivary gland utricle crypt of lieberkuhn of small intestine parotid gland spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function ATPase binding antioxidant activity protein binding enzyme binding ubiquitin-specific protease binding signaling receptor activity Cellular component cytoplasm integral component of membrane membrane Derlin-1-VIMP complex plasma membrane very-low-density lipoprotein particle integral component of endoplasmic reticulum membrane endoplasmic reticulum low-density lipoprotein particle Derlin-1 retrotranslocation complex cytoplasmic microtubule endoplasmic reticulum membrane Biological process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of gluconeogenesis establishment of protein localization negative regulation of interleukin-6 production response to glucose negative regulation of glycogen biosynthetic process cell redox homeostasis ER overload response response to redox state endoplasmic reticulum unfolded protein response negative regulation of glucose import retrograde protein transport, ER to cytosol negative regulation of macrophage apoptotic process ubiquitin-dependent ERAD pathway cellular response to insulin stimulus regulation of nitric oxide metabolic process cellular response to oxidative stress negative regulation of tumor necrosis factor production negative regulation of acute inflammatory response to antigenic stimulus cellular response to lipopolysaccharide intracellular protein transport negative regulation of inflammatory response negative regulation of nitric-oxide synthase biosynthetic process cellular oxidant detoxification protein ubiquitination Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 55829 109815 Ensembl ENSG00000131871 ENSMUSG00000075701 UniProt Q9BQE4 Q9BCZ4 RefSeq (mRNA) NM_203472 NM_018445 NM_024439 NM_001348246 RefSeq (protein) NP_060915 NP_982298 NP_001335175 NP_077759 Location (UCSC) Chr 15: 101.27 – 101.28 Mb Chr 7: 65.73 – 65.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[5]