SEMA4A
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.[5][6]
External IDsOMIM: 607292; MGI: 107560; HomoloGene: 8425; GeneCards: SEMA4A; OMA:SEMA4A - orthologs
Function
SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][6]
Clinical significance
A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[7]
Recently it has been identified as a novel therapeutic target in Multiple myeloma.[8]
