Semenogelin I

SEMG1
Identifiers
Aliases	SEMG1, CT103, SEMG, SGI, dJ172H20.2, Semenogelin I, semenogelin 1
External IDs	OMIM: 182140; GeneCards: SEMG1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,209,768 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; sperm; ; prostate; ; gallbladder; ; epithelium of colon; ; thymus; ; synovial joint; ; blood; ; islet of Langerhans; ; mucosa of nose;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; zinc ion binding;
Cellular component	extracellular region; extracellular exosome; nucleus; extracellular space; protein-containing complex;
Biological process	negative regulation of calcium ion import; insemination; antibacterial humoral response; positive regulation of serine-type endopeptidase activity; protein heterooligomerization; negative regulation of flagellated sperm motility; antimicrobial humoral response; coagulation; sperm capacitation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6406
	n/a
	ENSG00000124233
	n/a
	P04279
	n/a
	NM_198139; NM_003007
	n/a
	NP_002998
	n/a
	Wikidata
View/Edit Human

Semenogelin-1 is a protein that in humans is encoded by the SEMG1 gene.^[3]^[4]^[5] The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.^[5]