Semenogelin
From Wikipedia, the free encyclopedia
Semenogelin is a protein that is involved in the formation of a gel matrix that encases ejaculated spermatozoa, preventing capacitation.[1] It blocks capacitation mainly via inhibition of reactive oxygen species (ROS) generation.[1]
Proteolysis by prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely.[2] The cleavage products of the semenogelins constitute the main antibacterial components in human seminal plasma.[3]
There are two variants of the semenogelin protein: semenogelin 1 and semenogelin 2.
Semenogelin along with prostate-specific antigen, are commonly tested for during crime scene investigation.