SFI1

SFI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K2I
Identifiers
Aliases	SFI1, PISD, PPP1R139, hSfi1p, SFI1 centrin binding protein
External IDs	OMIM: 612765; MGI: 1926137; HomoloGene: 12707; GeneCards: SFI1; OMA:SFI1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,618,588 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,143,463 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right uterine tube; ; granulocyte; ; left testis; ; anterior pituitary; ; right testis; ; sural nerve; ; spleen; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	bronchus; ; trachea; ; lobar bronchus; ; spermatocyte; ; superior frontal gyrus; ; mesothelium of visceral serous pericardium; ; primary visual cortex; ; yolk sac; ; Rostral migratory stream; ; right ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatase binding; protein binding;
Cellular component	cytoplasm; centriole; cytosol; centrosome; cytoskeleton;
Biological process	negative regulation of phosphatase activity; G2/M transition of mitotic cell cycle; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	9814
	78887
	ENSG00000198089
	ENSMUSG00000023764
	A8K8P3
	Q3UZY0
	NM_001007467; NM_001258325; NM_001258326; NM_001258327; NM_014775
	NM_030207; NM_001363222; NM_001363223; NM_001363224
	NP_001007468; NP_001245254; NP_001245255; NP_001245256; NP_055590
	NP_084483; NP_001350151; NP_001350152; NP_001350153
	Wikidata
View/Edit Human	View/Edit Mouse

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. ^[5] It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication.^[6] SFI1 forms a complex with centrin 2.^[7]