SFRS12

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.^[5][6]

AliasesSREK1, SFRS12, SRrp508, SRrp86, splicing regulatory glutamic acid/lysine-rich protein 1, splicing regulatory glutamic acid and lysine rich protein 1

External IDsOMIM: 609268; MGI: 2145245; HomoloGene: 10581; GeneCards: SREK1; OMA:SREK1 - orthologs

Chr.Chromosome 5 (human)^[1]

End66,183,615 bp^[1]

Quick facts SREK1, Identifiers ...

SREK1
Identifiers
Aliases	SREK1, SFRS12, SRrp508, SRrp86, splicing regulatory glutamic acid/lysine-rich protein 1, splicing regulatory glutamic acid and lysine rich protein 1
External IDs	OMIM: 609268; MGI: 2145245; HomoloGene: 10581; GeneCards: SREK1; OMA:SREK1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q12.3 Start 66,139,971 bp[1] End 66,183,615 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 103,875,856 bp[2] End 103,911,116 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon right uterine tube corpus epididymis ventricular zone caput epididymis body of pancreas left lobe of thyroid gland right lobe of thyroid gland body of uterus Top expressed in genital tubercle tail of embryo Rostral migratory stream neural layer of retina yolk sac zygote pineal gland medullary collecting duct ventricular zone lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component spliceosomal complex nucleus nucleoplasm nuclear speck Biological process mRNA processing RNA splicing regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140890 218543 Ensembl ENSG00000153914 ENSMUSG00000032621 UniProt Q8WXA9 Q8BZX4 RefSeq (mRNA) NM_001077199 NM_001270492 NM_001270493 NM_139168 NM_001323527 NM_001323529 NM_001323533 NM_001323534 NM_001323535 NM_172592 NM_001361085 RefSeq (protein) NP_001070667 NP_001257421 NP_001310456 NP_001310458 NP_001310462 NP_001310463 NP_001310464 NP_631907 NP_766180 NP_001348014 Location (UCSC) Chr 5: 66.14 – 66.18 Mb Chr 13: 103.88 – 103.91 Mb PubMed search [3] [4]
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SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]^[6]