SFSWAP

Splicing factor, suppressor of white-apricot homolog is a protein in humans that is encoded by the SFSWAP gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesSFSWAP, SFRS8, SWAP, splicing factor SWAP homolog, splicing factor SWAP

External IDsOMIM: 601945; MGI: 101760; HomoloGene: 134548; GeneCards: SFSWAP; OMA:SFSWAP - orthologs

Chr.Chromosome 12 (human)^[1]

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SFSWAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5Z, 2E60
Identifiers
Aliases	SFSWAP, SFRS8, SWAP, splicing factor SWAP homolog, splicing factor SWAP
External IDs	OMIM: 601945; MGI: 101760; HomoloGene: 134548; GeneCards: SFSWAP; OMA:SFSWAP - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 131,711,081 bp[1] End 131,799,738 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,578,285 bp[2] End 129,648,448 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve tendon of biceps brachii olfactory bulb internal globus pallidus external globus pallidus beta cell right hemisphere of cerebellum pars reticulata cardia left ovary Top expressed in tail of embryo genital tubercle neural layer of retina ventricular zone zygote cerebellar cortex superior frontal gyrus primary visual cortex granulocyte thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding Cellular component nucleus Biological process mRNA processing RNA processing negative regulation of mRNA splicing, via spliceosome regulation of transcription, DNA-templated alternative mRNA splicing, via spliceosome transcription, DNA-templated RNA splicing mRNA 5'-splice site recognition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6433 231769 Ensembl ENSG00000061936 ENSMUSG00000029439 UniProt Q12872 Q3USH5 RefSeq (mRNA) NM_001261411 NM_004592 NM_152235 NM_001035259 NM_172276 NM_001359952 NM_001378915 NM_001378916 NM_001378917 RefSeq (protein) NP_001248340 NP_004583 NP_758480 NP_001346881 NP_001365844 NP_001365845 NP_001365846 Location (UCSC) Chr 12: 131.71 – 131.8 Mb Chr 5: 129.58 – 129.65 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified.^[5]