SHP099

SHP099
Clinical data
Drug class	SHP2 inhibitor
Identifiers
	IUPAC name 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine;
CAS Number	1801747-42-1;
PubChem CID	118238298;
ChemSpider	58171740;
ChEMBL	ChEMBL4060033;
PDB ligand	5OD (PDBe, RCSB PDB);
Chemical and physical data
Formula	C16H19Cl2N5
Molar mass	352.26 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(CCN(CC1)C2=CN=C(C(=N2)N)C3=C(C(=CC=C3)Cl)Cl)N;
	InChI InChI=1S/C16H19Cl2N5/c1-16(20)5-7-23(8-6-16)12-9-21-14(15(19)22-12)10-3-2-4-11(17)13(10)18/h2-4,9H,5-8,20H2,1H3,(H2,19,22); Key:YGUFCDOEKKVKJK-UHFFFAOYSA-N;

SHP099 is a drug that acts as an inhibitor of the protein tyrosine phosphatase enzyme SHP-2 (PTPN11). It was developed as a potential agent for the treatment of cancer, but while it is potent, orally active and effective at inhibiting SHP-2 activity and slowing tumor growth, it was not developed for clinical use because of dose-limiting side effects. However it continues to be widely used in cancer research and a number of related derivatives have been developed.^[1]^[2]^[3]^[4]^[5]^[6]^[7] It has also been used to research the role of SHP-2 in other processes such as regulation of bone growth during development.^[8]^[9]

Drug classSHP2 inhibitor

CAS Number

1801747-42-1

PubChem CID

118238298

ChemSpider

58171740

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SHP099

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References

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