SHR9352

SHR9352
Identifiers
	IUPAC name (1'S)-N-[2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethyl]spiro[1,3-dithiolane-2,4'-2,3-dihydro-1H-naphthalene]-1'-amine;
CAS Number	2095345-71-2 ;
PubChem CID	129049894;
CompTox Dashboard (EPA)	DTXSID901336695 ;
Chemical and physical data
Formula	C28H36N2OS2
Molar mass	480.73 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCC2(C1)C[C@](CCO2)(CCN[C@H]3CCC4(C5=CC=CC=C35)SCCS4)C6=CC=CC=N6;
	InChI InChI=1S/C28H36N2OS2/c1-2-8-23-22(7-1)24(10-13-28(23)32-19-20-33-28)29-17-14-26(25-9-3-6-16-30-25)15-18-31-27(21-26)11-4-5-12-27/h1-3,6-9,16,24,29H,4-5,10-15,17-21H2/t24-,26+/m0/s1; Key:WRBLHOVSELHRMG-AZGAKELHSA-N;

SHR9352 is a drug which acts as a potent and selective biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It was structurally derived from oliceridine by replacing the benzylic side chain with a cyclised group, although only some compounds in the series retained the desired biased agonist profile, with some derivatives such as compound 12 being potent, unbiased μ-opioid full agonists.^[1]

CAS Number

2095345-71-2^Y

PubChem CID

129049894

CompTox Dashboard (EPA)

DTXSID901336695

FormulaC₂₈H₃₆N₂OS₂

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SHR9352

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Identifiers

IUPAC name (1'S)-N-[2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethyl]spiro[1,3-dithiolane-2,4'-2,3-dihydro-1H-naphthalene]-1'-amine
CAS Number	2095345-71-2^Y
PubChem CID	129049894
CompTox Dashboard (EPA)	DTXSID901336695
Chemical and physical data
Formula	C₂₈H₃₆N₂OS₂
Molar mass	480.73 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CCC2(C1)C[C@](CCO2)(CCN[C@H]3CCC4(C5=CC=CC=C35)SCCS4)C6=CC=CC=N6
InChI InChI=1S/C28H36N2OS2/c1-2-8-23-22(7-1)24(10-13-28(23)32-19-20-33-28)29-17-14-26(25-9-3-6-16-30-25)15-18-31-27(21-26)11-4-5-12-27/h1-3,6-9,16,24,29H,4-5,10-15,17-21H2/t24-,26+/m0/s1 Key:WRBLHOVSELHRMG-AZGAKELHSA-N