SLC22A7

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.^[5][6][7]

AliasesSLC22A7, NLT, OAT2, solute carrier family 22 member 7, hOAT11

External IDsOMIM: 604995; MGI: 1859559; HomoloGene: 21328; GeneCards: SLC22A7; OMA:SLC22A7 - orthologs

Chr.Chromosome 6 (human)^[1]

End43,305,538 bp^[1]

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SLC22A7
Identifiers
Aliases	SLC22A7, NLT, OAT2, solute carrier family 22 member 7, hOAT11
External IDs	OMIM: 604995; MGI: 1859559; HomoloGene: 21328; GeneCards: SLC22A7; OMA:SLC22A7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,295,694 bp[1] End 43,305,538 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 46,743,109 bp[2] End 46,749,383 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule renal medulla vena cava olfactory bulb glomerulus metanephric glomerulus human kidney right testis Skeletal muscle tissue of rectus abdominis Top expressed in right kidney human kidney left lobe of liver proximal tubule embryo embryo morula convoluted tubule proximal convoluted tubule thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function organic anion transmembrane transporter activity protein binding inorganic anion exchanger activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane membrane Biological process ion transport organic anion transport transmembrane transport anion transmembrane transport inorganic anion transport sodium-independent organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10864 108114 Ensembl ENSG00000137204 ENSMUSG00000067144 UniProt Q9Y694 Q5T051 Q91WU2 RefSeq (mRNA) NM_006672 NM_153320 NM_144856 RefSeq (protein) NP_006663 NP_696961 NP_659105 Location (UCSC) Chr 6: 43.3 – 43.31 Mb Chr 17: 46.74 – 46.75 Mb PubMed search [3] [4]
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The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]