SLC35H1

SLC35H1
Identifiers
Aliases	SLC35H1, BA394O2.1, C20orf5, CGI-15, OVCOV1, solute carrier family 35 member C2, Solute carrier family 35 member H1
External IDs	MGI: 2385166; GeneCards: SLC35H1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,364,458 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	165,129,789 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; right uterine tube; ; granulocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; right adrenal cortex; ; left adrenal cortex; ; right ovary; ; minor salivary glands;
	Top expressed in
	lacrimal gland; ; granulocyte; ; duodenum; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; yolk sac; ; jejunum; ; superior frontal gyrus; ; primary visual cortex; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antiporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment membrane; membrane; endoplasmic reticulum-Golgi intermediate compartment; nucleoplasm; Golgi apparatus;
Biological process	protein O-linked fucosylation; fucosylation; negative regulation of gene expression; positive regulation of Notch signaling pathway; UDP-glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51006
	228875
	ENSG00000080189
	ENSMUSG00000017664
	Q9NQQ7
	Q8VCX2
NM_001281457; NM_001281458; NM_001281459; NM_001281460; NM_015945;
	NM_173073; NM_173179
NM_001252573; NM_001252574; NM_001252575; NM_144893; NM_001363015;
	NM_001363016
NP_001268386; NP_001268387; NP_001268388; NP_001268389; NP_057029;
	NP_775096; NP_775271
NP_001239502; NP_001239503; NP_001239504; NP_659142; NP_001349944;
	NP_001349945
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 35 member H1 is a protein that in humans is encoded by the SLC35H1 gene (previously SLC35C2).^[5]^[6]^[7] This protein was originally thought to act as a GDP-fucose transporter like its homolog SLC35C1, but later research has suggested that this is not the case.^[8]

AliasesSLC35H1, BA394O2.1, C20orf5, CGI-15, OVCOV1, solute carrier family 35 member C2, Solute carrier family 35 member H1

External IDsMGI: 2385166; GeneCards: SLC35H1

Chr.Chromosome 20 (human)^[1]

End46,364,458 bp^[1]

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Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene.^[7]

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SLC35H1

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