SLITRK6
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
SLIT and NTRK-like protein 6 is a protein that in humans is encoded by the SLITRK6 gene.[5][6]
External IDsOMIM: 609681; MGI: 2443198; HomoloGene: 12986; GeneCards: SLITRK6; OMA:SLITRK6 - orthologs
| SLITRK6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | SLITRK6, DFNMYP, SLIT and NTRK like family member 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609681; MGI: 2443198; HomoloGene: 12986; GeneCards: SLITRK6; OMA:SLITRK6 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.[5][6]
Clinical significance
As a drug target
The protein is the target for the antibody-drug conjugate ASG-15ME which is in phase 1 clinical trials for urothelial cancer.[8]
