SMG5

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.^[5][6][7] This protein contains a PIN domain that appears to have mutated the residues in the active site.^[8]

AliasesSMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor

External IDsOMIM: 610962; MGI: 2447364; GeneCards: SMG5

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 1 (human)^[1]

Quick facts Identifiers, Aliases ...

SMG5
Identifiers
Aliases	SMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
External IDs	OMIM: 610962; MGI: 2447364; GeneCards: SMG5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HWY
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,249,224 bp[1] End 156,282,825 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,243,567 bp[2] End 88,269,645 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle anterior pituitary right adrenal gland granulocyte right hemisphere of cerebellum C1 segment right adrenal cortex left adrenal cortex skin of leg Top expressed in spermatocyte spermatid superior frontal gyrus neural layer of retina ventricular zone lip muscle of thigh seminiferous tubule dentate gyrus of hippocampal formation granule cell tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 2A binding histone deacetylase binding protein binding telomeric DNA binding ubiquitin protein ligase binding ribonuclease activity ribonucleoprotein complex binding telomerase RNA binding Cellular component cytoplasm cytosol nucleus telomerase holoenzyme complex Biological process regulation of dephosphorylation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA export from nucleus regulation of telomere maintenance regulation of telomere maintenance via telomerase regulation of RNA stability RNA phosphodiester bond hydrolysis telomere maintenance via telomerase Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 23381 229512 Ensembl ENSG00000198952 ENSMUSG00000001415 UniProt Q9UPR3 Q6ZPY2 RefSeq (mRNA) NM_015327 NM_001323614 NM_001323615 NM_001323616 NM_001323617 NM_173188 NM_178246 RefSeq (protein) NP_001310543 NP_001310544 NP_001310545 NP_001310546 NP_056142 NP_839977 Location (UCSC) Chr 1: 156.25 – 156.28 Mb Chr 3: 88.24 – 88.27 Mb PubMed search [3] [4]
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