SMS (gene)

PDBOrtholog search: PDBe RCSB

AliasesSMS, MRSR, SPMSY, SRS, SpS, spermine synthase, MRXSSR

External IDsOMIM: 300105; MGI: 3705601; HomoloGene: 88709; GeneCards: SMS; OMA:SMS - orthologs

Chr.X chromosome (human)^[1]

SMS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C6K, 3C6M
Identifiers
Aliases	SMS, MRSR, SPMSY, SRS, SpS, spermine synthase, MRXSSR
External IDs	OMIM: 300105; MGI: 3705601; HomoloGene: 88709; GeneCards: SMS; OMA:SMS - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.11 Start 21,940,709 bp[1] End 21,994,837 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta ganglionic eminence right adrenal cortex left adrenal gland left adrenal cortex human kidney endometrium ventricular zone islet of Langerhans ovary n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity spermine synthase activity Cellular component cytosol extracellular exosome Biological process spermine biosynthetic process spermine metabolic process polyamine biosynthetic process methionine metabolic process polyamine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6611 671878 Ensembl ENSG00000102172 n/a UniProt P52788 P97355 RefSeq (mRNA) NM_001258423 NM_004595 XM_001473434 RefSeq (protein) NP_001245352 NP_004586 NP_033240 NP_001346114 Location (UCSC) Chr X: 21.94 – 21.99 Mb n/a PubMed search [2] [3]
Wikidata
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SMS is a gene that encodes the enzyme spermine synthase in humans.^[4][5][6] The protein encoded by this gene belongs to the spermidine/spermine synthases family. This gene encodes a ubiquitous enzyme of polyamine metabolism.^[6]